Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | VDR | P11473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488016 | 0.89 | AKR1A1 (0.60) | LMNASMN1; SMN2APEX1MEN1KMT2A | |
| SCHEMBL9047901 | 0.87 | LMNA (0.52) | LMNASMN1; SMN2APEX1MEN1KMT2A | |
| SCHEMBL9047096 | 0.84 | KMT2A (0.55) | LMNASMN1; SMN2MEN1KMT2AAKR1A1 | |
| SCHEMBL11266396 | 0.83 | LMNA (0.74) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9048106 | 0.83 | MEN1 (0.55) | LMNASMN1; SMN2APEX1MEN1KMT2A | |
| SCHEMBL11306156 | 0.83 | APEX1 (0.62) | LMNASMN1; SMN2APEX1MEN1KMT2A | |
| SCHEMBL11263079 | 0.82 | APEX1 (0.70) | LMNASMN1; SMN2APEX1MEN1KMT2A | |
| SCHEMBL9048800 | 0.81 | LMNA (0.51) | LMNASMN1; SMN2APEX1MEN1KMT2A | |
| SCHEMBL10487970 | 0.79 | AKR1A1 (0.57) | LMNAAPEX1MEN1KMT2AAKR1A1 | |
| SCHEMBL2762171 | 0.78 | APEX1 (0.79) | LMNASMN1; SMN2APEX1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0019440-A1 | Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them | PFIZER INC. (US) | 1980-11-26 | — | — | EP | claimed |
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| US-4209527-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |