Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1A1 | P14550 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487970 | 0.91 | AKR1A1 (0.57) | AKR1A1AKR1B1MAPTTP53LMNA | |
| SCHEMBL11269563 | 0.89 | LMNA (0.62) | AKR1A1AKR1B1MAPTLMNAALDH1A1 | |
| SCHEMBL10487985 | 0.89 | AKR1B1 (0.72) | AKR1A1AKR1B1MAPTTP53LMNA | |
| SCHEMBL9047901 | 0.86 | LMNA (0.52) | AKR1A1AKR1B1MAPTTP53LMNA | |
| SCHEMBL9047096 | 0.86 | KMT2A (0.55) | AKR1A1AKR1B1MAPTLMNAALDH1A1 | |
| SCHEMBL10487922 | 0.85 | LMNA (0.61) | MAPTTP53LMNAALDH1A1ALOX12 | |
| SCHEMBL10487926 | 0.84 | MEN1 (0.61) | MAPTTP53TSHRMEN1KMT2A | |
| SCHEMBL10487989 | 0.82 | MAPT (0.54) | AKR1A1AKR1B1MAPTTP53ALDH1A1 | |
| SCHEMBL10487916 | 0.82 | MAPT (0.65) | AKR1A1AKR1B1MAPTTP53ALDH1A1 | |
| SCHEMBL10487883 | 0.81 | HDAC1 (0.64) | MAPTTP53ALDH1A1NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |