Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyraxinine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyraxinine SCHEMBL2456848 | 0.88 | RAB9A (0.55) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 | |
| Pyraxinine SCHEMBL4683017 | 0.87 | RAB9A (0.53) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| Nitric Acid SCHEMBL4682608 | 0.82 | L3MBTL1 (0.50) | CYP11B1CYP11B2L3MBTL1KMT2AMEN1 | |
| Nitric Acid SCHEMBL4682603 | 0.81 | CYP11B1 (0.49) | CYP11B1CYP11B2L3MBTL1KMT2AMEN1 | |
| Nitric Acid SCHEMBL4682605 | 0.81 | CYP11B1 (0.49) | CYP11B1CYP11B2L3MBTL1KMT2AMEN1 | |
| Phenylguanidine SCHEMBL2847797 | 0.80 | MAPT (0.50) | L3MBTL1KMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL4678812 | 0.77 | CYP11B1 (0.55) | CYP11B1CYP11B2L3MBTL1KMT2AMEN1 | |
| SCHEMBL4678817 | 0.77 | CYP11B1 (0.55) | CYP11B1CYP11B2L3MBTL1KMT2AMEN1 | |
| SCHEMBL30226193 | 0.76 | RAB9A (0.49) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL162008 | 0.74 | RAB9A (0.65) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4341769-A | VASODILATOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-07-27 | — | — | US | disclosed |
| EP-0038161-A1 | 2,6-Diaminonebularines, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1981-10-21 | — | — | EP | disclosed |