Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylguanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylguanidine SCHEMBL256023 | 0.85 | ALDH1A1 (0.58) | MAPTALDH1A1GAAKMT2ALMNA | |
| Phenylguanidine SCHEMBL28414520 | 0.84 | HSD17B10 (0.52) | MAPTALDH1A1GAAKMT2ALMNA | |
| Phenylguanidine SCHEMBL300643 | 0.84 | TP53 (0.56) | MAPTALDH1A1GAAKMT2AMEN1 | |
| Phenylguanidine SCHEMBL1950328 | 0.84 | TP53 (0.56) | MAPTALDH1A1GAAKMT2AMEN1 | |
| Phenylguanidine SCHEMBL29249611 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1GAAKMT2ALMNA | |
| Phenylguanidine SCHEMBL11092906 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1GAAKMT2ALMNA | |
| Phenylguanidine SCHEMBL4027020 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1GAAKMT2ALMNA | |
| Nitric Acid SCHEMBL2852035 | 0.83 | PEPD (0.52) | MAPTALDH1A1GAAKMT2ALMNA | |
| Phenylguanidine SCHEMBL8887604 | 0.82 | TP53 (0.54) | MAPTALDH1A1GAAKMT2AMEN1 | |
| Nitric Acid SCHEMBL5350529 | 0.82 | L3MBTL1 (0.52) | MAPTALDH1A1GAALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1703199-A | Aggregate with enhanced deformability comprising at least three amphiphiles for improved transport through a semi-permeable barrier and use of non-invasive drugs in vivo, in particular through the skin | IDEA AG (DE) | 2005-11-30 | — | — | CN | claimed |
| US-11780858-B2 | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds | SPRINT BIOSCIENCE AB (SE) | 2023-10-10 | — | — | US | disclosed |
| CN-116041320-A | Pyridinamine-pyridone compounds and pyrimidinamine-pyridone compounds | 思普瑞特生物科学公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-116041321-A | Pyridinamine-pyridone compounds and pyrimidinamine-pyridone compounds | 思普瑞特生物科学公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-4169581-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | Sprint Bioscience AB (SE) | 2023-04-26 | — | — | EP | disclosed |
| CN-111094271-B | Pyridinamine-pyridinone compounds and pyrimidinamine-pyridinone compounds | 思普瑞特生物科学公司 | 2023-02-28 | — | — | CN | disclosed |
| EP-3672948-B1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2022-10-05 | — | — | EP | disclosed |
| US-20220177495-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2022-06-09 | — | — | US | disclosed |
| US-11208423-B2 | Pyridinamine-pyridone and pyrimidinamine- pyridone compounds | SPRINT BIOSCIENCE AB (SE) | 2021-12-28 | — | — | US | disclosed |
| US-20200361963-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2020-11-19 | — | — | US | disclosed |
| WO-2000078731-A1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | CELLTECH R&D LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |
| CN-1043531-C | Pyrimidine derivatives and a process for production thereof | NOVATIS AG (CH) | 1999-06-02 | — | — | CN | disclosed |
| CN-1077713-A | Pyrimidine derivatives and preparation method thereof | CIBA GEIGY AG (CH) | 1993-10-27 | — | — | CN | disclosed |
| EP-0347866-B1 | ANILINOPYRIMIDINE DERIVATIVES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1993-04-07 | — | — | EP | disclosed |
| EP-0270111-B1 | PYRIMIDINE DERIVATIVES AND AGRICULTURAL OR HORTICULTURAL FUNGICIDAL COMPOSITION CONTANING THE SAME | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-05-15 | — | — | EP | disclosed |
| US-4992438-A | Pyrimidine derivatives, process for preparing the same and agricultural or horticultural fungicidal composition containing the same | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-02-12 | — | — | US | disclosed |
| US-4943675-A | Anilinopyrimidine derivatives | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1990-07-24 | — | — | US | disclosed |
| EP-0347866-A2 | Anilinopyrimidine derivatives | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1989-12-27 | — | — | EP | disclosed |
| EP-0270111-A1 | Pyrimidine derivatives and agricultural or horticultural fungicidal composition contaning the same | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |
| US-3976787-A | VASOCONSTRICTION | ARMOUR PHARMACEUTICAL COMPANY (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780858-B2 | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds | PDXK, PLPBP, PNPO | MAPT 2405/4885ALDH1A1 1779/4885GAA 3804/4885 |
| US-11208423-B2 | Pyridinamine-pyridone and pyrimidinamine- pyridone compounds | PDXK, PLPBP, PNPO | MAPT 2292/4885ALDH1A1 1797/4885GAA 3882/4885 |
| US-20220177495-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | PDXK, PLPBP, PNPO | MAPT 2405/4885ALDH1A1 1779/4885GAA 3804/4885 |
| US-20200361963-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | PDXK, PLPBP, PNPO | MAPT 2292/4885ALDH1A1 1797/4885GAA 3882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.