Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | C1S | P09871 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11830753 | 0.88 | LMNA (0.36) | LMNAALDH1A1PRSS1PRSS2C1S | |
| SCHEMBL11409212 | 0.88 | RAPGEF4 (0.42) | LMNAALDH1A1PRSS1PRSS2C1S | |
| SCHEMBL11412481 | 0.88 | HTT (0.50) | LMNAALDH1A1RAPGEF4HPGDMEN1 | |
| SCHEMBL11842079 | 0.88 | ALDH1A1 (0.38) | LMNAALDH1A1PRSS1PRSS2C1S | |
| SCHEMBL11410732 | 0.85 | LMNA (0.41) | LMNAALDH1A1RAPGEF4HPGDNLRP3 | |
| SCHEMBL11848097 | 0.85 | ALDH1A1 (0.43) | LMNAALDH1A1PRSS1PRSS2C1S | |
| SCHEMBL11407137 | 0.85 | RAPGEF4 (0.34) | LMNAALDH1A1PRSS1PRSS2C1S | |
| SCHEMBL11834635 | 0.85 | LMNA (0.32) | LMNAALDH1A1PRSS1PRSS2C1S | |
| SCHEMBL11417465 | 0.85 | RAPGEF4 (0.37) | LMNAALDH1A1PRSS1PRSS2C1S | |
| SCHEMBL11408930 | 0.84 | RAPGEF4 (0.38) | LMNAALDH1A1PRSS1PRSS2C1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4216229-A | 1-AMIDINO-3-PHENYLUREAS | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216230-A | Method for alleviating hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |