Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | MGAM | O43451 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | SI | P14410 | 5/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932417 | 0.84 | MAPT (0.76) | MEN1KMT2AMAPTPKMCTSK | |
| SCHEMBL6834853 | 0.84 | MAPT (0.76) | MEN1KMT2AMAPTPKMCTSK | |
| SCHEMBL148211 | 0.84 | MAPT (0.68) | MEN1KMT2AMAPTPKMHTR2A | |
| SCHEMBL6835648 | 0.84 | MAPT (0.76) | MEN1KMT2AMAPTPKMCTSK | |
| SCHEMBL2087167 | 0.83 | MAPT (0.66) | MEN1KMT2AMAPTPKMCTSK | |
| SCHEMBL17520555 | 0.82 | HTR2A (0.56) | MEN1KMT2AMAPTPKMHTR2A | |
| SCHEMBL19168545 | 0.82 | HTR2A (0.56) | MEN1KMT2AMAPTPKMHTR2A | |
| SCHEMBL19161105 | 0.82 | HTR2A (0.56) | MEN1KMT2AMAPTPKMHTR2A | |
| SCHEMBL4860329 | 0.82 | GPR84 (0.68) | MEN1KMT2AMAPTPKMHTR2A | |
| SCHEMBL22478760 | 0.82 | MAPT (0.64) | MEN1KMT2AMAPTPKMHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4283410-A | HYPOTENSIVE AGENTS | MILES LABORATORIES, INC. (US) | 1981-08-11 | — | — | US | claimed |
| US-4361566-A | Tetrahydro β-carbolines having antihypertensive activity | MILES LABORATORIES, INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4291039-A | Tetrahydro β-carbolines having anti-hypertensive activity | MILES LABORATORIES, INC. (US) | 1981-09-22 | — | — | US | disclosed |