Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 17/20 | 0.60 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1125943 | 0.84 | GAA (0.64) | NR1H2NR1H3ESR1GAAMAPT | |
| SCHEMBL11043805 | 0.77 | P2RX3 (0.41) | NR1H2NR1H3ESR1FABP3FABP4 | |
| SCHEMBL6024428 | 0.75 | ESR1 (0.51) | NR1H2NR1H3ESR1GAAMAPT | |
| SCHEMBL1124681 | 0.75 | NR1H2 (1.00) | NR1H2NR1H3MAPTNPSR1 | |
| SCHEMBL1125732 | 0.73 | NR1H2 (0.81) | NR1H2NR1H3 | |
| SCHEMBL1124620 | 0.73 | NR1H2 (0.81) | NR1H2NR1H3 | |
| SCHEMBL1124692 | 0.73 | NR1H2 (0.95) | NR1H2NR1H3MAPTNPSR1 | |
| SCHEMBL1125782 | 0.72 | NR1H2 (0.78) | NR1H2NR1H3 | |
| SCHEMBL2821238 | 0.71 | FABP4 (0.46) | GAAMAPTNPSR1FABP3FABP4 | |
| SCHEMBL10946606 | 0.71 | KDM4E (0.46) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | claimed |