Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.60 |
| ▸ | DRD2 | P14416 | 15/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266845 | 0.92 | PDE3B (0.62) | PDE3BPDE3AP2RY12DRD2DRD4 | |
| SCHEMBL11276115 | 0.85 | PDE3B (0.58) | PDE3BPDE3AP2RY12DRD2DRD4 | |
| SCHEMBL30712216 | 0.83 | DRD2 (0.57) | DRD2ACHEMAOBDRD4DRD3 | |
| SCHEMBL19732216 | 0.83 | DRD2 (0.57) | DRD2ACHEMAOBDRD4DRD3 | |
| SCHEMBL11273281 | 0.80 | POLB (0.50) | PDE3BPDE3AP2RY12DRD2 | |
| SCHEMBL11272074 | 0.80 | PDE3B (0.54) | PDE3BPDE3AP2RY12MAOB | |
| SCHEMBL11275661 | 0.80 | PDE3B (0.49) | PDE3BPDE3AP2RY12DRD2DRD4 | |
| SCHEMBL18496112 | 0.78 | DRD2 (0.49) | DRD2ACHEMAOBDRD4DRD3 | |
| SCHEMBL29923245 | 0.78 | DRD2 (0.49) | DRD2ACHEMAOBDRD4DRD3 | |
| SCHEMBL11271536 | 0.78 | DRD2 (0.52) | DRD2ACHEMAOBDRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |