Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11271989 | 0.85 | PDE3B (0.42) | PDE3BPDE3AP2RY12POLBPKM | |
| SCHEMBL11285306 | 0.81 | PDE3B (0.46) | PDE3BPDE3AP2RY12POLBPKM | |
| SCHEMBL11266845 | 0.81 | PDE3B (0.62) | PDE3BPDE3AP2RY12POLBPKM | |
| SCHEMBL11270566 | 0.80 | PDE3B (0.60) | PDE3BPDE3AP2RY12MAOB | |
| SCHEMBL11277251 | 0.79 | KDM4E (0.46) | PDE3BPDE3APOLBPKMCYP1A2 | |
| SCHEMBL11272206 | 0.78 | LMNA (0.48) | PDE3BPDE3ACYP1A2CYP2C19TNKS2 | |
| SCHEMBL11068508 | 0.78 | LMNA (0.54) | PDE3BPDE3ACYP1A2CYP2C19TNKS2 | |
| SCHEMBL11281640 | 0.76 | POLB (0.42) | PDE3BPDE3APOLBPKMCYP1A2 | |
| SCHEMBL11273753 | 0.76 | TNKS2 (0.47) | PDE3BPDE3APOLBCYP1A2CYP2C19 | |
| SCHEMBL11276115 | 0.76 | PDE3B (0.58) | PDE3BPDE3AP2RY12POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |