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SCHEMBL11270592

SCHEMBL11270592

N=C(N)Nc1ccc(C(=O)Oc2ccc(C=CC(=O)OCC(=O)NCc3ccccc3)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.52
▸ KDM4E B2RXH2 2/20 0.49
▸ L3MBTL1 Q9Y468 2/20 0.48
▸ POLB P06746 2/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ KMT2A Q03164 4/20 0.47
▸ MEN1 O00255 3/20 0.47
▸ MAPT P10636 2/20 0.47
▸ HPGD P15428 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11270588 1.00 LMNA (0.52) LMNAKDM4EL3MBTL1POLBTDP1
SCHEMBL11275960 0.90 KMT2A (0.59) LMNAKDM4EL3MBTL1POLBTDP1
SCHEMBL11275962 0.90 KMT2A (0.59) LMNAKDM4EL3MBTL1POLBTDP1
SCHEMBL11277441 0.88 HPGD (0.58) LMNAKDM4EL3MBTL1POLBKMT2A
SCHEMBL11272864 0.86 KMT2A (0.46) LMNAKDM4EL3MBTL1TDP1KMT2A
SCHEMBL11272853 0.86 KMT2A (0.46) LMNAKDM4EL3MBTL1TDP1KMT2A
SCHEMBL11281436 0.84 KMT2A (0.47) LMNAKDM4ETDP1KMT2AMEN1
SCHEMBL11281443 0.84 KMT2A (0.47) LMNAKDM4ETDP1KMT2AMEN1
SCHEMBL11268595 0.82 KMT2A (0.45) KDM4ETDP1KMT2AMEN1MAPT
SCHEMBL11268601 0.82 KMT2A (0.45) KDM4ETDP1KMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4310533-A INHIBITING PLASMIN AND-OR TRYSIN ACTIVITY ONO PHARMACEUTICAL CO., LTD. (JP) 1982-01-12 — — US disclosed