Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PAICS | P22234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678307 | 0.86 | FGFR3 (0.52) | HRH3KDRFGFR3 | |
| SCHEMBL17023093 | 0.86 | FGFR3 (0.55) | HRH3KDRFGFR3 | |
| SCHEMBL17023135 | 0.81 | FAAH (0.53) | HRH3 | |
| SCHEMBL17023123 | 0.80 | HRH3 (0.52) | HRH3KDRLCKSRCMAPK14 | |
| SCHEMBL17023089 | 0.79 | FGFR3 (0.48) | KDRFGFR3ABL1BCRLCK | |
| SCHEMBL17023037 | 0.79 | HPGDS (0.44) | FGFR3KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL17023109 | 0.77 | HRH3 (0.41) | HRH3FGFR3KDM4EALDH1A1ABL1 | |
| SCHEMBL1127069 | 0.75 | FGFR3 (0.49) | KDRFGFR3PAICS | |
| SCHEMBL17023074 | 0.73 | FGFR3 (0.59) | FGFR3KDM4EDRD2MEN1KMT2A | |
| SCHEMBL12678226 | 0.73 | FGFR3 (0.72) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |