Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15515228 | 0.92 | KDM4E (0.45) | KEAP1SMN1; SMN2KDM4EALDH1A1GLA | |
| SCHEMBL5419101 | 0.87 | KEAP1 (0.47) | HRH3KEAP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4042388 | 0.83 | HRH3 (0.42) | HRH3KEAP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5319576 | 0.83 | KEAP1 (0.47) | HRH3KEAP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL646005 | 0.81 | KDM4E (0.50) | KEAP1SMN1; SMN2KDM4EALDH1A1GLA | |
| SCHEMBL12937 | 0.81 | ALDH1A1 (0.54) | HRH3KEAP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4526651 | 0.80 | KEAP1 (0.52) | HRH3KEAP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11833413 | 0.78 | SIGMAR1 (0.40) | HRH3ALDH1A1CYP1A2CARM1PRMT6 | |
| SCHEMBL13019 | 0.78 | KDM4E (0.56) | HRH3KEAP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5616506 | 0.77 | CXCR4 (0.46) | HRH3SMN1; SMN2KDM4EALDH1A1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE31071-E | 6-Aza-3H-1,4-benzodiazepines | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1982-11-02 | — | — | US | disclosed |
| US-4008223-A | SPASMOLYTIC, ANTIPHLOGISTIC, TRANQUILIZER | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) | 1977-02-15 | — | — | US | disclosed |