Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935830 | 0.89 | GABRP (0.39) | DRD2DRD3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL6120653 | 0.85 | CYP2D6 (0.38) | KDM1ADRD2DRD3CYP2D6SLC6A2 | |
| SCHEMBL6083553 | 0.83 | HTR3A (0.44) | KDM1AHTR2AHTR2C | |
| SCHEMBL24449205 | 0.80 | DRD2 (0.38) | DRD2DRD3CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL27752202 | 0.77 | KDM1A (0.44) | KDM1AHTR2C | |
| SCHEMBL853178 | 0.77 | KDM1A (0.35) | KDM1ACYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL122872 | 0.76 | KDM1A (0.50) | KDM1A | |
| SCHEMBL27855972 | 0.76 | KDM1A (0.50) | KDM1A | |
| SCHEMBL1904517 | 0.76 | KDM1A (0.50) | KDM1A | |
| SCHEMBL14741159 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062018-A1 | Novel phenyl-piperidines | Aktiebolaget Hässle (SE) | 1982-10-06 | — | — | EP | disclosed |