Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257484 | 0.91 | ALDH1A1 (0.45) | LMNANPSR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11264969 | 0.90 | ALDH1A1 (0.48) | LMNAGLO1KMT2AMEN1HPGD | |
| SCHEMBL11269214 | 0.89 | LMNA (0.43) | LMNANPSR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11253650 | 0.88 | CACNA1F (0.45) | LMNANPSR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11266663 | 0.88 | MAPT (0.44) | LMNANPSR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11266095 | 0.88 | LMNA (0.40) | LMNANPSR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11254374 | 0.88 | HTT (0.47) | LMNACYP2D6CYP2C9CYP2C19GAA | |
| SCHEMBL11270360 | 0.87 | MEN1 (0.40) | LMNANPSR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11271125 | 0.87 | LMNA (0.48) | LMNANPSR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11257451 | 0.87 | LMNA (0.40) | LMNANPSR1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360520-A | 1,4-Dihydropyridazine compounds, and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |