Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | CES2 | O00748 | 2/20 | 0.58 |
| ▸ | CES1 | P23141 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28057486 | 0.82 | CES2 (0.53) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL3070427 | 0.80 | ALDH1A1 (0.62) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL16458740 | 0.79 | CES2 (0.57) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL3069389 | 0.79 | ALDH1A1 (0.60) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL22721136 | 0.77 | CES2 (0.54) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL29110154 | 0.76 | MGAM (0.52) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL2142791 | 0.75 | POLB (0.56) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL11400057 | 0.75 | CES2 (0.51) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL13058838 | 0.75 | POLB (0.64) | POLBALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL11754791 | 0.74 | POLB (1.00) | POLBALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360520-A | 1,4-Dihydropyridazine compounds, and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |