Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275736 | 0.89 | ABL1 (0.45) | KDM4CTLR9TLR8TLR7MMP2 | |
| SCHEMBL11271590 | 0.86 | NPC1 (0.46) | KDM4CFGFR1FGFR2MAPTHSD17B10 | |
| SCHEMBL11271918 | 0.82 | MMP2 (0.49) | KDM4CTLR9TLR8TLR7MAPT | |
| Water SCHEMBL11275606 | 0.81 | MMP2 (0.48) | KDM4CTLR9TLR8TLR7MAPT | |
| SCHEMBL20436746 | 0.80 | KDM4C (0.43) | KDM4CMAPTHSD17B10ALDH1A1HPGD | |
| SCHEMBL11270413 | 0.78 | CYP11B2 (0.58) | KDM4CFGFR1TLR8TLR7MAPT | |
| SCHEMBL11263840 | 0.77 | KDM4C (0.38) | KDM4CFGFR1FGFR2TLR9TLR8 | |
| SCHEMBL11265691 | 0.75 | TLR8 (0.39) | TLR9TLR8TLR7MAPTNPC1 | |
| SCHEMBL11268351 | 0.75 | TLR8 (0.39) | TLR9TLR8TLR7 | |
| SCHEMBL31578022 | 0.74 | CYP1A2 (0.46) | KDM4CMAPTHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |