Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10870781 | 0.84 | TDP1 (0.53) | TDP1TSHRMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL13554407 | 0.83 | AAK1 (0.45) | TSHRALDH1A1CYP3A4CYP2C9MAOB | |
| SCHEMBL5048744 | 0.82 | TAAR1 (0.56) | MAOB | |
| SCHEMBL12672292 | 0.82 | TSHR (0.46) | TSHRALDH1A1CYP3A4CYP2C9GAA | |
| SCHEMBL2073759 | 0.82 | TDP1 (0.54) | TDP1TSHRMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL109648 | 0.81 | TDP1 (0.64) | TDP1TSHRMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL14407437 | 0.81 | TDP1 (0.59) | TDP1TSHRMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL2693322 | 0.81 | ADRB2 (0.41) | TSHRCYP3A4CYP2C9 | |
| SCHEMBL27037634 | 0.80 | PTGS1 (0.53) | TSHRAPPCYP2C9PTGS1LMNA | |
| SCHEMBL14123467 | 0.80 | TSHR (0.42) | TDP1TSHRAPPCYP2C9MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4331805-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1982-05-25 | — | — | US | disclosed |
| US-4236003-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1980-11-25 | — | — | US | disclosed |
| US-4157443-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1979-06-05 | — | — | US | disclosed |