SCHEMBL11272147

SCHEMBL11272147

Clc1ccc2c(c1)C(Cl)c1ccccc1CO2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.43
DRD2 P14416 2/20 0.42
DRD3 P35462 2/20 0.42
CHRM2 P08172 1/20 0.42
HTR1A P08908 1/20 0.42
ADRA2A P08913 1/20 0.42
GABRA1 P14867 1/20 0.42
ADRA2B P18089 1/20 0.42
ADRA2C P18825 1/20 0.42
DRD1 P21728 1/20 0.42
DRD4 P21917 1/20 0.42
SLC6A2 P23975 1/20 0.42
ADRA1D P25100 1/20 0.42
HTR2A P28223 1/20 0.42
HTR2C P28335 1/20 0.42
SLC6A4 P31645 1/20 0.42
ADRA1A P35348 1/20 0.42
HRH1 P35367 1/20 0.42
ADRA1B P35368 1/20 0.42
HTR2B P41595 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10728083 0.85 MAOB (0.42) MAOBDRD2DRD3CHRM2HTR1A
SCHEMBL11277012 0.85 HTR2B (0.40) MAOBDRD2DRD3CHRM2HTR1A
SCHEMBL16385819 0.84 HTR2A (0.43) MAOBDRD2DRD3CHRM2HTR1A
SCHEMBL5400526 0.82 HTR2A (0.44) MAOBDRD2DRD3HTR2AHTR2C
SCHEMBL10881346 0.82 KMT2A (0.39) HTR1AADRA2ASLC6A2HTR2AHTR2C
SCHEMBL10559305 0.82 DRD2 (0.42) MAOBDRD2DRD3SLC6A2HTR2A
SCHEMBL11278667 0.80 MAOB (0.42) MAOBDRD2DRD3CHRM2HTR1A
SCHEMBL10444078 0.80 HTR2A (0.41) MAOBDRD2DRD3CHRM2HTR1A
SCHEMBL8797275 0.79 MAOB (0.44) MAOBDRD2DRD3TERTMAPT
SCHEMBL11275290 0.78 ALDH1A1 (0.51) DRD2DRD3HTR1ADRD1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4335122-A DIURETICS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1982-06-15 US disclosed