Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 12/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11302095 | 0.86 | PRKCI (0.49) | PRKCIGRM4TLR9TLR8TLR7 | |
| SCHEMBL11272019 | 0.83 | PRKCI (0.36) | PRKCIGRM4TLR9TLR8TLR7 | |
| SCHEMBL11263840 | 0.80 | KDM4C (0.38) | PRKCIGRM4TLR9TLR8TLR7 | |
| SCHEMBL11262069 | 0.78 | DYRK1A (0.44) | TLR9TLR8TLR7GSK3B | |
| SCHEMBL11265691 | 0.73 | TLR8 (0.39) | TLR9TLR8TLR7 | |
| SCHEMBL11260933 | 0.72 | NPC1 (0.49) | TLR9TLR8TLR7 | |
| SCHEMBL11262645 | 0.72 | SREBF2 (0.41) | TLR9TLR7PDE3BPDE3ACDK5 | |
| SCHEMBL11269149 | 0.71 | PDE3B (0.49) | PDE3BPDE3A | |
| SCHEMBL229607 | 0.70 | KMT2A (0.44) | PDE3BPDE3A | |
| SCHEMBL10705931 | 0.69 | DYRK3 (0.46) | GSK3BCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |