Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.56 |
| ▸ | EP300 | Q09472 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | CTRC | Q99895 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266702 | 0.83 | MMP1 (0.47) | HDAC6EP300HDAC1HDAC2HDAC8 | |
| SCHEMBL11394505 | 0.81 | POLB (0.53) | HDAC6EP300MEN1KMT2APOLB | |
| SCHEMBL11264078 | 0.75 | HDAC6 (0.74) | HDAC6EP300HDAC1HDAC2HDAC8 | |
| SCHEMBL11259949 | 0.75 | HDAC6 (0.62) | HDAC6EP300HDAC1HDAC2HDAC8 | |
| SCHEMBL12914631 | 0.75 | HDAC6 (0.43) | HDAC6EP300HDAC1HDAC8 | |
| SCHEMBL19923714 | 0.72 | HDAC6 (0.55) | HDAC6EP300HDAC1HDAC2HDAC8 | |
| SCHEMBL17358735 | 0.72 | EP300 (0.66) | EP300F2PLGELANECTSG | |
| SCHEMBL19923523 | 0.71 | EP300 (0.56) | HDAC6EP300HDAC1HDAC2HDAC8 | |
| SCHEMBL19923616 | 0.71 | EP300 (0.56) | HDAC6EP300HDAC1HDAC2HDAC8 | |
| SCHEMBL15131570 | 0.71 | EP300 (1.00) | HDAC6EP300F2PLGELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005647-B1 | HYDANTOIN COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | Lilly Industries Limited (GB) | 1982-06-09 | — | — | EP | disclosed |
| US-4293563-A | ANTIASTHMATICS | LILLY INDUSTRIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4241073-A | ASTHMA | LILLY INDUSTRIES LIMITED (GB) | 1980-12-23 | — | — | US | disclosed |
| EP-0005647-A1 | Hydantoin compounds, their preparation and pharmaceutical formulations containing them | Lilly Industries Limited (GB) | 1979-11-28 | — | — | EP | disclosed |