Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270533 | 0.84 | KDM4E (0.44) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL11282334 | 0.84 | PDE3B (0.44) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL11276023 | 0.84 | F11 (0.50) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL11268673 | 0.84 | KDM4E (0.46) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL11284124 | 0.82 | PDE3A (0.43) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL11270806 | 0.82 | PDE3B (0.47) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL10925920 | 0.81 | MCL1 (0.46) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL11275791 | 0.81 | MEN1 (0.41) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| Nitrobenzene SCHEMBL11274618 | 0.80 | CTSV (0.42) | ALDH1A1MEN1KMT2AKDM4EPDE5A | |
| SCHEMBL10927340 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AKDM4EPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |