Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.36 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL450386 | 0.82 | EGFR (0.40) | EGFRTDO2IKBKBCHUKDYRK1A | |
| SCHEMBL16896218 | 0.81 | EGFR (0.39) | EGFRTDO2IKBKBCHUKDYRK1A | |
| SCHEMBL20657077 | 0.73 | EGFR (0.47) | EGFRTDO2PIK3CDPIK3CA | |
| SCHEMBL19518057 | 0.72 | MAPK1 (0.35) | EGFRAHRPIM3 | |
| SCHEMBL10744986 | 0.72 | LMNA (0.44) | EGFRTDO2RAD52 | |
| SCHEMBL88355 | 0.71 | KMT2A (0.47) | EGFRAHRRAD52SMARCA2 | |
| SCHEMBL16416592 | 0.71 | RAD52 (0.31) | RAD52SMARCA2PIM3 | |
| SCHEMBL28401294 | 0.71 | EGFR (0.44) | EGFRTDO2PIK3CDPIK3CA | |
| SCHEMBL23852799 | 0.68 | AHR (0.38) | EGFRTDO2IKBKBCHUKDYRK1A | |
| SCHEMBL7744423 | 0.65 | AHR (0.35) | AHRPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015786-B1 | IMIDAZO AND PYRIMIDO-PYRIDO INDOLES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | SYNTHELABO (FR) | 1982-04-21 | — | — | EP | claimed |
| EP-0015786-A1 | Imidazo and pyrimido-pyrido indoles, their preparation and medicines containing them | SYNTHELABO (FR) | 1980-09-17 | — | — | EP | claimed |
| EP-0015786-B1 | IMIDAZO AND PYRIMIDO-PYRIDO INDOLES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | SYNTHELABO (FR) | 1982-04-21 | — | — | EP | disclosed |
| EP-0015786-B1 | IMIDAZO AND PYRIMIDO-PYRIDO INDOLES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | SYNTHELABO (FR) | 1982-04-21 | — | — | EP | disclosed |
| EP-0015786-A1 | Imidazo and pyrimido-pyrido indoles, their preparation and medicines containing them | SYNTHELABO (FR) | 1980-09-17 | — | — | EP | disclosed |
| EP-0015786-A1 | Imidazo and pyrimido-pyrido indoles, their preparation and medicines containing them | SYNTHELABO (FR) | 1980-09-17 | — | — | EP | disclosed |
| EP-0015786-A1 | Imidazo and pyrimido-pyrido indoles, their preparation and medicines containing them | SYNTHELABO (FR) | 1980-09-17 | — | — | EP | disclosed |