SCHEMBL1127558

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1127217	0.95	LMNA (0.36)	ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
	SCHEMBL1126633	0.95	MAPT (0.36)	ALDH1A1SMN1; SMN2GRIN2DGRIN3BGRIN1
	SCHEMBL1126471	0.92	LMNA (0.38)	ALDH1A1NPC1RAB9AMAPTHSD17B10
	SCHEMBL1126636	0.92	GRIN2D (0.38)	ALDH1A1SMN1; SMN2GRIN2DGRIN3BGRIN1
	SCHEMBL1126732	0.91	MAPT (0.38)	ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
	SCHEMBL1126481	0.91	KCNA5 (0.41)	ALDH1A1SMN1; SMN2NPC1RAB9AMAPT
	SCHEMBL1127916	0.91	MAPT (0.36)	ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
	SCHEMBL1126434	0.91	MAPT (0.39)	ALDH1A1NPC1RAB9AMAPTHSD17B10
	SCHEMBL1996170	0.90	KMT2A (0.37)	ALDH1A1SMN1; SMN2NPC1RAB9AMAPT
	SCHEMBL1993424	0.90	SLC2A1 (0.37)	ALDH1A1SMN1; SMN2NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.