SCHEMBL1127660

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2778701	0.85	TSHR (0.48)	TRPA1TSHRAOC3HTR2ACCR1
	SCHEMBL5198423	0.82	TRPA1 (0.43)	TRPA1TSHRPOLBTAAR1LMNA
	SCHEMBL953748	0.82	TRPA1 (0.43)	TRPA1TSHRPOLBAOC3HTR2A
	SCHEMBL1445763	0.78	CCR1 (0.42)	TRPA1TSHRPOLBHTR2AHRH1
	SCHEMBL6938022	0.78	HRH1 (0.44)	TRPA1TSHRPOLBAOC3HTR2A
	SCHEMBL12949533	0.78	HRH1 (0.56)	TRPA1TSHRTAAR1HTR2AHRH1
	SCHEMBL8678630	0.78	TSHR (0.43)	TRPA1TSHRPOLBTAAR1HTR2A
	SCHEMBL22323261	0.78	TSHR (0.43)	TRPA1TSHRPOLBTAAR1HTR2A
	SCHEMBL7295721	0.78	TRPA1 (0.43)	TRPA1TSHRPOLBTAAR1HTR2A
	SCHEMBL7515845	0.78	TRPA1 (0.43)	TRPA1TSHRPOLBTAAR1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.