Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264839 | 0.85 | NR1H2 (0.35) | NR1H2NR1H3MEN1MAPK1KMT2A | |
| SCHEMBL11278797 | 0.85 | MEN1 (0.38) | NR1H2NR1H3MEN1MAPK1KMT2A | |
| SCHEMBL11276954 | 0.83 | IL1B (0.35) | NR1H2NR1H3IL1BMEN1MAPK1 | |
| SCHEMBL11262158 | 0.83 | MLYCD (0.39) | NR1H2NR1H3MEN1MAPK1KMT2A | |
| Hydrochloric Acid SCHEMBL11266398 | 0.83 | NR1H2 (0.34) | NR1H2NR1H3MEN1MAPK1KMT2A | |
| SCHEMBL11272364 | 0.82 | NR1H2 (0.35) | NR1H2NR1H3MEN1MAPK1KMT2A | |
| SCHEMBL11267064 | 0.81 | KMT2A (0.43) | MEN1KMT2ATSHRHSD17B10ALDH1A1 | |
| SCHEMBL11267619 | 0.81 | HTT (0.46) | NR1H2NR1H3MEN1MAPK1KMT2A | |
| SCHEMBL11266609 | 0.77 | MLYCD (0.40) | NR1H2NR1H3MEN1MAPK1KMT2A | |
| SCHEMBL11624158 | 0.76 | MEN1 (0.49) | NR1H2NR1H3MEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4267193-A | N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1981-05-12 | — | — | US | disclosed |