Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | MC3R | P41968 | 2/20 | 0.41 |
| ▸ | MC1R | Q01726 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28838840 | 0.74 | CHRNA7 (0.62) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL2863110 | 0.72 | CHRNA7 (0.68) | TACR1CHRNA7CHRNB2CHRNA4GRIN2B | |
| SCHEMBL30191825 | 0.71 | PKM (0.48) | POLBL3MBTL1TACR1NPC1 | |
| SCHEMBL6012064 | 0.69 | CHRNA7 (0.68) | TACR1CHRNA7CHRNB2CHRNA4GRIN2B | |
| SCHEMBL13972054 | 0.69 | S1PR5 (0.51) | POLBL3MBTL1S1PR1S1PR5 | |
| SCHEMBL159263 | 0.68 | S1PR1 (0.47) | POLBL3MBTL1S1PR1S1PR5TACR3 | |
| SCHEMBL15556894 | 0.68 | ALDH1A1 (0.35) | CHRNA7SMN1; SMN2NOTUM | |
| SCHEMBL7810455 | 0.68 | GRIN2B (0.46) | L3MBTL1S1PR1S1PR5TACR3GRIN2B | |
| SCHEMBL9473816 | 0.68 | S1PR5 (0.50) | POLBL3MBTL1S1PR1S1PR5NPC1 | |
| SCHEMBL51920 | 0.67 | S1PR5 (0.81) | S1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4350691-A | ANTIEMETICS | BEECHAM GROUP LIMITED (GB) | 1982-09-21 | — | — | US | disclosed |
| EP-0031219-A1 | Aniline derivatives | BEECHAM GROUP PLC (GB) | 1981-07-01 | — | — | EP | disclosed |