Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10179020 | 0.79 | NR1I2 (0.46) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL1155698 | 0.78 | TSHR (0.35) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL19292971 | 0.76 | RXFP1 (0.36) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL23005306 | 0.74 | HSD17B10 (0.33) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12877259 | 0.73 | HSD11B1 (0.49) | ALDH1A1KMT2ASMN1; SMN2HSD17B10TSHR | |
| SCHEMBL21067213 | 0.72 | ALDH1A1 (0.39) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL23005307 | 0.72 | RXFP1 (0.33) | ALDH1A1MEN1MAPTKMT2ANPC1 | |
| SCHEMBL5220990 | 0.71 | ATP4A (0.51) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2519357 | 0.71 | KDM4E (0.53) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL13654991 | 0.71 | HSD11B1 (0.38) | KMT2ASMN1; SMN2HSD17B10TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746451-B1 | BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-07-12 | — | — | EP | disclosed |
| WO-2019149657-A1 | BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-08-08 | — | — | WO | disclosed |
| US-4358453-A | ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1982-11-09 | — | — | US | disclosed |