Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | METAP2 | P50579 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17538518 | 0.81 | SMN1; SMN2 (0.70) | SMN1; SMN2GAAALDH1A1HPGDLMNA | |
| SCHEMBL28282453 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2GAAALDH1A1HPGDLMNA | |
| SCHEMBL28284047 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2GAAALDH1A1HPGDLMNA | |
| SCHEMBL11277786 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2GAAALDH1A1HPGDLMNA | |
| SCHEMBL29502862 | 0.75 | MEN1 (0.67) | SMN1; SMN2GAAMETAP2KDM4ETP53 | |
| SCHEMBL10352138 | 0.75 | MEN1 (0.67) | SMN1; SMN2GAAMETAP2KDM4ETP53 | |
| Ebselen Diselenide SCHEMBL10520791 | 0.72 | METAP2 (1.00) | ALDH1A1HPGDLMNAMETAP2KDM4E | |
| SCHEMBL10351936 | 0.71 | NPC1 (0.68) | SMN1; SMN2GAAALDH1A1LMNAMETAP2 | |
| SCHEMBL10352157 | 0.70 | METAP2 (0.75) | SMN1; SMN2GAAALDH1A1METAP2KDM4E | |
| SCHEMBL10523571 | 0.70 | METAP2 (0.75) | METAP2KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257306-B1 | DISELENOBIS BENZOIC ACID AMIDES OF PRIMARY HETEROCYCLIC AMINES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOUNDS COMPRISING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0257306-A1 | Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and pharmaceutical compounds comprising the same | A. Nattermann & Cie. GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |