SCHEMBL11278337

SCHEMBL11278337

CCOC(=O)C(C)(C(=O)OCC)c1ccc([N+](=O)[O-])c(C(F)(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 9/20 0.48
CYP3A4 P08684 2/20 0.48
PGR P06401 1/20 0.48
CES2 O00748 1/20 0.45
ABCB11 O95342 1/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
CYP1A2 P05177 1/20 0.45
GLA P06280 1/20 0.45
ADORA3 P0DMS8 1/20 0.45
CHRM1 P11229 1/20 0.45
CYP2C9 P11712 1/20 0.45
ALOX15 P16050 1/20 0.45
TSHR P16473 1/20 0.45
TBXA2R P21731 1/20 0.45
AADAC P22760 1/20 0.45
MAPK1 P28482 1/20 0.45
CYP2C19 P33261 1/20 0.45
ADRA1A P35348 1/20 0.45
HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15111213 0.86 AR (0.45) ARCYP3A4PGRCES2ABCB11
SCHEMBL142930 0.85 THRB (0.44) ALDH1A1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL3659021 0.83 AR (0.47) ARCYP3A4PGRCES2ABCB11
SCHEMBL7035586 0.82 THRB (0.52) CYP3A4ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL11152796 0.81 NPSR1 (0.46) ALDH1A1LMNACYP2C19SMN1; SMN2MAPT
SCHEMBL23070471 0.79 NPSR1 (0.39) CYP3A4CES2ABCB11ALDH1A1LMNA
SCHEMBL11266735 0.79 AR (0.42) ARCES2ALDH1A1LMNATSHR
SCHEMBL28537382 0.79 THRB (0.42) CES2ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL7035878 0.77 ALDH1A1 (0.52) CYP3A4ALDH1A1LMNACYP1A2MAPK1
SCHEMBL13208348 0.76 AR (0.54) ARCYP3A4PGRCES2ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4337264-A ANALGESICS, ANTIINFLAMMATORY AGENTS AND FUNGICIDES CIBA-GEIGY CORPORATION (US) 1982-06-29 US disclosed
US-4316850-A ANTINFLAMMATORY AGENTS CIBA-GEIGY CORPORATION (US) 1982-02-23 US disclosed
US-4264619-A Tertiary aminoacids CIBA-GEIGY CORPORATION (US) 1981-04-28 US disclosed
US-4163788-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1979-08-07 US disclosed
US-4126691-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1978-11-21 US disclosed
US-3993763-A ALPHA-(CYCLIC TERTIARY AMINO-PHENYL)-ALIPHATIC ACIDS CIBA-GEIGY CORPORATION (US) 1976-11-23 US disclosed
US-3936467-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1976-02-03 US disclosed