Sugi Predict

Sugi Predict / Compounds / SCHEMBL1127909

SCHEMBL1127909

SCHEMBL1127909

Cc1cccc(Cl)c1CN

nearest known ligand 0.70

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 3/20 0.52
▸ DPP4 P27487 2/20 0.48
▸ PNMT P11086 2/20 0.46
▸ HTR2A P28223 1/20 0.43
▸ HTR2C P28335 1/20 0.43
▸ HTR2B P41595 1/20 0.43
▸ GAA P10253 2/20 0.42
▸ ALDH1A1 P00352 1/20 0.41
▸ PKM P14618 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ AKR1B1 P15121 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ P2RX7 Q99572 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL110460 0.83 TAAR1 (0.64) TAAR1DPP4PNMTHTR2AHTR2C
SCHEMBL394915 0.83 CYP1A2 (0.43) TAAR1DPP4HTR2AHTR2BALDH1A1
Hydrochloric Acid SCHEMBL28845596 0.81 DPP4 (0.52) DPP4PNMTHTR2AHTR2CHTR2B
Hydrochloric Acid SCHEMBL7895201 0.80 TAAR1 (0.61) TAAR1DPP4PNMTHTR2AHTR2C
Hydrochloric Acid SCHEMBL6726928 0.80 CYP3A4 (0.42) TAAR1HTR2AHTR2CHTR2BALDH1A1
SCHEMBL9861759 0.79 TAAR1 (0.43) TAAR1HTR2AHTR2CHTR2BGAA
SCHEMBL726569 0.79 TAAR1 (0.43) TAAR1HTR2AHTR2CHTR2BALDH1A1
SCHEMBL3667290 0.79 TAAR1 (0.38) TAAR1DPP4PNMTHTR2AHTR2C
SCHEMBL14567074 0.77 TAAR1 (0.41) TAAR1HTR2AHTR2CHTR2BGAA
SCHEMBL14127124 0.77 TAAR1 (0.41) TAAR1HTR2AHTR2CHTR2BGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869038-B1 SUBSTITUTED 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDIN-2-YLAMINE COMPOUNDS AND THEIR USE FOR PRODUCING DRUGS GRUENENTHAL GMBH (DE) 2009-07-08 — — EP claimed
CN-1186332-C Novel thyroid receptor ligands and method II KAROBIO AB (SE) 2005-01-26 — — CN claimed
CN-1337953-A Novel thyroid receptor ligands and method II KAROBIO AB (SE) 2002-02-27 — — CN claimed
EP-3609868-B1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS RAQUALIA PHARMA INC (JP) 2023-10-18 — — EP disclosed
US-20230149382-A1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS ASAHI KASEI PHARMA CORPORATION (JP) 2023-05-18 — — US disclosed
US-20230149382-A1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS ASAHI KASEI PHARMA CORPORATION (JP) 2023-05-18 — — US disclosed
US-11174268-B2 Benzenesulfonamide compouds and their use as therapeutic agents XENON PHARMACEUTICALS INC. (CA) 2021-11-16 — — US disclosed
US-11077100-B2 Tetrahydroquinoline derivatives as P2X7 receptor antagonists RAQUALIA PHARMA INC. (JP) 2021-08-03 — — US disclosed
US-20210171537-A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS XENON PHARMACEUTICALS INC. (CA) 2021-06-10 — — US disclosed
US-20210085667-A1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS RAQUALIA PHARMA INC. (JP) 2021-03-25 — — US disclosed
US-20200405706-A1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS RAQUALIA PHARMA INC. (JP) 2020-12-31 — — US disclosed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 — — EP disclosed
WO-2001005230-A1 ALPHA-HYDROXY-GAMMA-[[(CARBOCYCLIC-OR HETEROCYCLIC-SUBSTITUTED)AMINO]CARBONYL]ALKANAMIDE DERIVATIVES AND USES THEREOF MERCK & CO., INC. (US) 2001-01-25 — — WO disclosed
WO-2001000213-A1 SRC KINASE INHIBITOR COMPOUNDS MERCK & CO., INC. (US) 2001-01-04 — — WO disclosed
CN-1230173-A Substituted N-arylmethylamino derivatives of cyclobutene-3,-4-diones AMERICAN HOME PROD (US) 1999-09-29 — — CN disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 — — EP disclosed
US-5780505-A ADMINISTERING AS SMOOTH MUSCLE RELAXANT AMERICAN HOME PRODUCTS CORPORATION (US) 1998-07-14 — — US disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 — — WO disclosed
US-4017631-A MICROBIOCIDES JANSSEN PHARMACEUTICA N.V. (BE) 1977-04-12 — — US disclosed
US-3991202-A ANTIMICROBIALS JANSSEN PHARMACEUTICA N.V. (BE) 1976-11-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200405706-A1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS P2RX7, P2RX3, P2RX1 TAAR1 276/4885DPP4 1037/4885PNMT 2406/4885
US-11077100-B2 Tetrahydroquinoline derivatives as P2X7 receptor antagonists P2RX7, P2RX3, P2RX1 TAAR1 276/4885DPP4 1037/4885PNMT 2406/4885
US-11174268-B2 Benzenesulfonamide compouds and their use as therapeutic agents KCND2, SCN1A, CACNA1D TAAR1 1459/4885DPP4 2202/4885PNMT 758/4885
US-20210171537-A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS SCN1A, SCN1B, SCN2B TAAR1 1715/4885DPP4 1736/4885PNMT 483/4885
US-20230149382-A1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS P2RX7, P2RX3, P2RX1 TAAR1 276/4885DPP4 1037/4885PNMT 2406/4885
US-20210085667-A1 TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS P2RX7, P2RX3, P2RX1 TAAR1 276/4885DPP4 1037/4885PNMT 2406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.