SCHEMBL11279273

SCHEMBL11279273

CC(C)C(=O)Oc1ccc(C(=O)C(N)C(C)(C)C)cc1OC(=O)C(C)C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 3/20 0.51
ADRB2 P07550 1/20 0.44
ADRA2A P08913 1/20 0.44
DRD2 P14416 1/20 0.44
ADRA2C P18825 1/20 0.44
DRD1 P21728 1/20 0.44
ADRA1A P35348 1/20 0.44
DRD3 P35462 1/20 0.44
ELANE P08246 3/20 0.41
KDM4E B2RXH2 2/20 0.40
GAA P10253 2/20 0.40
TSHR P16473 2/20 0.40
ALDH1A1 P00352 1/20 0.40
RAB9A P51151 1/20 0.40
PDE4A P27815 2/20 0.37
PDE4B Q07343 2/20 0.37
PDE4C Q08493 2/20 0.37
PDE4D Q08499 2/20 0.37
FGFR1 P11362 2/20 0.37
PDK1 Q15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11277579 0.99 ALOX15 (0.50) ALOX15ADRB2ADRA2ADRD2ADRA2C
Hydrochloric Acid SCHEMBL11283581 0.85 PDE4A (0.41) ALOX15ADRB2ADRA2ADRD2ADRA2C
SCHEMBL11279668 0.85 ALOX15 (0.40) ALOX15ADRB2ADRA2ADRD2ADRA2C
SCHEMBL11290593 0.84 ALDH1A1 (0.46) ADRB2ELANEKDM4EGAATSHR
Hydrochloric Acid SCHEMBL11282567 0.83 ADRB2 (0.47) ADRB2ELANEKDM4EGAATSHR
Hydrochloric Acid SCHEMBL11276274 0.82 ALOX15 (0.53) ALOX15ADRB2KDM4EGAATSHR
SCHEMBL11281880 0.81 KMT2A (0.44) KDM4EALDH1A1RAB9AMAPTSMN1; SMN2
Hydrochloric Acid SCHEMBL11278973 0.81 ALDH1A1 (0.38) ALOX15ADRB2KDM4EGAATSHR
SCHEMBL11286225 0.80 MAPT (0.43) KDM4EGAATSHRALDH1A1RAB9A
Hydrochloric Acid SCHEMBL11281624 0.80 KMT2A (0.43) KDM4EALDH1A1RAB9AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US disclosed
US-RE30241-E BRONCHODILATION, ADRENERGIC STIMULANTS STERLING DRUG INC. (US) 1980-03-25 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed