Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 5/20 | 0.53 |
| ▸ | ACE | P12821 | 8/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.52 |
| ▸ | DPP3 | Q9NY33 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11459782 | 0.93 | ACE (0.54) | CMA1ACEACE2DPP3SLC6A2 | |
| SCHEMBL683506 | 0.93 | ACE (0.54) | CMA1ACEACE2DPP3SLC6A2 | |
| SCHEMBL11278066 | 0.93 | ACE (0.54) | CMA1ACEACE2DPP3SLC6A2 | |
| SCHEMBL11287257 | 0.91 | ACE (0.54) | CMA1ACEACE2DPP3SLC6A2 | |
| SCHEMBL11285557 | 0.89 | CMA1 (0.54) | CMA1ACEACE2 | |
| Alacepril SCHEMBL34559 | 0.89 | ACE (0.55) | CMA1ACEACE2DPP3SLC6A2 | |
| Alacepril SCHEMBL683027 | 0.89 | ACE (0.55) | CMA1ACEACE2DPP3SLC6A2 | |
| Alacepril SCHEMBL677447 | 0.89 | ACE (0.55) | CMA1ACEACE2DPP3SLC6A2 | |
| Alacepril SCHEMBL5058556 | 0.89 | ACE (0.55) | CMA1ACEACE2DPP3SLC6A2 | |
| Alacepril SCHEMBL11460465 | 0.89 | ACE (0.55) | CMA1ACEACE2DPP3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007477-B1 | 1-(3-MERCAPTO-2-METHYLPROPANOYL)PROLYL AMINO ACID DERIVATIVES AND SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 1982-04-28 | — | — | EP | disclosed |
| US-4248883-A | ANTIHYPERTENSION AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1981-02-03 | — | — | US | disclosed |
| EP-0007477-A1 | 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives and salts thereof, processes for their preparation, and pharmaceutical compositions containing such compounds | Dainippon Pharmaceutical Co., Ltd. (JP) | 1980-02-06 | — | — | EP | disclosed |