Alcohol

Alcohol

SCHEMBL11279304

CCO.COc1ccc(C(=O)Oc2cc(C(OS(C)(=O)=O)C(N)C(C)(C)C)ccc2OC(C)=O)cc1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.42
GAA P10253 1/20 0.42
THRB P10828 1/20 0.42
KMT2A Q03164 7/20 0.40
CCR5 P51681 2/20 0.37
TSHR P16473 1/20 0.37
BACE1 P56817 1/20 0.35
MAPT P10636 4/20 0.35
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
ALOX12 P18054 1/20 0.35
ALDH1A1 P00352 3/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
MEN1 O00255 3/20 0.34
TDP1 Q9NUW8 1/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alcohol SCHEMBL11286082 1.00 TP53 (0.42) TP53GAATHRBKMT2ACCR5
Alcohol SCHEMBL11277070 0.91 CCR5 (0.36) TP53GAATHRBKMT2ACCR5
Alcohol SCHEMBL11287407 0.91 CCR5 (0.36) TP53GAATHRBKMT2ACCR5
Alcohol SCHEMBL11290214 0.88 GAA (0.36) TP53GAATHRBKMT2ATSHR
Alcohol SCHEMBL11283321 0.87 TSHR (0.36) TP53GAATHRBKMT2ATSHR
Alcohol SCHEMBL11290646 0.84 TSHR (0.38) THRBKMT2ATSHRMAPTALOX12
Alcohol SCHEMBL11284113 0.83 TSHR (0.37) TP53GAATHRBKMT2ATSHR
Alcohol SCHEMBL11282468 0.83 THRB (0.34) TP53GAATHRBTSHRMAPT
Alcohol SCHEMBL11290095 0.82 KMT2A (0.42) TP53GAATHRBKMT2ACCR5
Alcohol SCHEMBL11288246 0.82 GAA (0.36) GAATHRBKMT2AMAPTESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US claimed
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US disclosed
US-RE30241-E BRONCHODILATION, ADRENERGIC STIMULANTS STERLING DRUG INC. (US) 1980-03-25 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed