Alcohol

Alcohol

SCHEMBL11287407

CC(=O)Oc1ccc(C(OS(C)(=O)=O)C(N)C(C)(C)C)cc1OC(=O)c1ccc(C)cc1.CCO

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 2/20 0.36
ALDH1A1 P00352 4/20 0.34
TSHR P16473 2/20 0.34
GAA P10253 2/20 0.34
KDM4E B2RXH2 2/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 3/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TP53 P04637 1/20 0.33
THRB P10828 1/20 0.33
LMNA P02545 2/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
CYP3A4 P08684 1/20 0.32
HIF1A Q16665 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
PRSS1 P07477 1/20 0.32
ACR P10323 1/20 0.32
ADRB2 P07550 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alcohol SCHEMBL11277070 1.00 CCR5 (0.36) CCR5ALDH1A1TSHRGAAKDM4E
Alcohol SCHEMBL11283321 0.96 TSHR (0.36) ALDH1A1TSHRGAAKDM4ERAB9A
Alcohol SCHEMBL11290646 0.93 TSHR (0.38) ALDH1A1TSHRRAB9AKMT2ASMN1; SMN2
Alcohol SCHEMBL11286082 0.91 TP53 (0.42) CCR5ALDH1A1TSHRGAARAB9A
Alcohol SCHEMBL11279304 0.91 TP53 (0.42) CCR5ALDH1A1TSHRGAARAB9A
Alcohol SCHEMBL11282266 0.89 ESR1 (0.38) ALDH1A1TSHRGAAKDM4ERAB9A
Alcohol SCHEMBL11282468 0.89 THRB (0.34) ALDH1A1TSHRGAATP53THRB
Alcohol SCHEMBL11290103 0.88 ALOX15 (0.42) TSHRGAARAB9AKMT2ASMN1; SMN2
Alcohol SCHEMBL11285931 0.88 LMNA (0.32) ALDH1A1TSHRGAAKDM4ERAB9A
Alcohol SCHEMBL11284113 0.87 TSHR (0.37) ALDH1A1TSHRGAAKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US claimed
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US disclosed
US-RE30241-E BRONCHODILATION, ADRENERGIC STIMULANTS STERLING DRUG INC. (US) 1980-03-25 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed