Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371820 | 0.84 | MEN1 (0.59) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL1668185 | 0.84 | CYP1A2 (0.59) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL23897642 | 0.83 | MAPT (0.59) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL10990213 | 0.82 | KDM4E (0.58) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL468878 | 0.81 | ALOX15 (0.61) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL22769512 | 0.81 | ALOX15 (0.61) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL1769610 | 0.81 | MAPT (0.74) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL29414366 | 0.81 | MAPT (0.74) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL1769607 | 0.81 | MAPT (0.74) | MAPTKDM4EL3MBTL1APAF1POLB | |
| SCHEMBL27426182 | 0.81 | MAPT (0.74) | MAPTKDM4EL3MBTL1APAF1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4319029-A | DIURETICS, ANTIMETABOLIC AGENTS, HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0033797-A1 | 1-Hydroxyalkanamine tetrahydrocarbazoles, their preparation, pharmaceutical compositions containing same and their preparation, intermediates therefor and their preparation | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-08-19 | — | — | EP | disclosed |
| US-4235903-A | DIURETICS, MINERALCORTICOID ACTIVITY, HYPERTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-25 | — | — | US | disclosed |