Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.57 |
| ▸ | CMA1 | P23946 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PEPD | P12955 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388885 | 1.00 | ACE (0.58) | ACEACE2CMA1HSD17B10KDM4E | |
| SCHEMBL7388881 | 1.00 | ACE (0.58) | ACEACE2CMA1HSD17B10KDM4E | |
| SCHEMBL11338055 | 0.94 | ACE (0.54) | ACEACE2CMA1HSD17B10KDM4E | |
| Alacepril SCHEMBL11458085 | 0.92 | ACE (0.51) | ACEACE2CMA1CTRB1SLC6A2 | |
| SCHEMBL11334873 | 0.89 | ACE (0.59) | ACEACE2CMA1HSD17B10SLC6A2 | |
| SCHEMBL11279851 | 0.88 | CMA1 (0.57) | ACEACE2CMA1CTRB1 | |
| SCHEMBL29868291 | 0.88 | OPRM1 (0.59) | F2CTRB1SLC6A2OPRM1 | |
| SCHEMBL31184433 | 0.87 | SLC6A2 (0.63) | ACECMA1SLC6A2OPRM1 | |
| SCHEMBL11091524 | 0.87 | SLC6A2 (0.63) | ACECMA1SLC6A2OPRM1 | |
| Alacepril SCHEMBL34559 | 0.86 | ACE (0.55) | ACEACE2CMA1HSD17B10SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007477-B1 | 1-(3-MERCAPTO-2-METHYLPROPANOYL)PROLYL AMINO ACID DERIVATIVES AND SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 1982-04-28 | — | — | EP | disclosed |
| US-4248883-A | ANTIHYPERTENSION AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1981-02-03 | — | — | US | disclosed |
| EP-0007477-A1 | 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives and salts thereof, processes for their preparation, and pharmaceutical compositions containing such compounds | Dainippon Pharmaceutical Co., Ltd. (JP) | 1980-02-06 | — | — | EP | disclosed |