Alacepril

SCHEMBL11458085

CC(=O)SCC(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O.CC(CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	ACE	P12821	8/20	0.51

▸	SLC6A2	P23975	1/20	0.51

▸	ACE2	Q9BYF1	4/20	0.50

▸	CMA1	P23946	2/20	0.50

▸	OPRM1	P35372	1/20	0.48

▸	CTRB1	P17538	1/20	0.48

▸	DPP3	Q9NY33	1/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Alacepril SCHEMBL683027	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
Alacepril SCHEMBL20126832	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
Alacepril SCHEMBL11460465	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
Alacepril SCHEMBL5058556	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
Alacepril SCHEMBL677447	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
Alacepril SCHEMBL28035498	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
Alacepril SCHEMBL3204613	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
Alacepril SCHEMBL34559	0.95	ACE (0.55)	ACESLC6A2ACE2CMA1OPRM1
SCHEMBL11338055	0.92	ACE (0.54)	ACESLC6A2ACE2CMA1CTRB1
SCHEMBL11279566	0.92	ACE (0.58)	ACESLC6A2ACE2CMA1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0007477-A1	1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives and salts thereof, processes for their preparation, and pharmaceutical compositions containing such compounds	Dainippon Pharmaceutical Co., Ltd. (JP)	1980-02-06	—	—	EP	disclosed