SCHEMBL11279664

SCHEMBL11279664

Cc1ccncc1CC(N)=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT3 Q9NTG7 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
SOST Q9BQB4 1/20 0.41
CYP2C9 P11712 2/20 0.39
NAMPT P43490 1/20 0.39
HTT P42858 1/20 0.39
CCNC P24863 2/20 0.39
CDK8 P49336 2/20 0.39
GRM2 Q14416 1/20 0.39
SLC22A12 Q96S37 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
KDM4C Q9H3R0 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2E1 P05181 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C8 P10632 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2A6 P11509 1/20 0.38
CYP2B6 P20813 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26337351 0.85 SIRT3 (0.50) SIRT3TDP1HTTCCNCCDK8
SCHEMBL3582588 0.83 SIRT3 (0.47) SIRT3TDP1SOSTCYP2C9NAMPT
SCHEMBL10788672 0.82 SIRT3 (0.51) SIRT3TDP1SOSTCYP2C9NAMPT
SCHEMBL2434056 0.81 SIRT3 (0.50) SIRT3TDP1SOSTCYP2C9NAMPT
SCHEMBL14357993 0.79 KDM4E (0.44) SIRT3TDP1SLC22A12KDM4CCA12
SCHEMBL11273660 0.78 ROCK2 (0.40) SIRT3TDP1CCNCCDK8SLC22A12
SCHEMBL3587236 0.77 PKM (0.43) SIRT3TDP1SOSTALDH1A1KMT2A
SCHEMBL212818 0.76
SCHEMBL30335585 0.76
SCHEMBL1515284 0.76 CA2 (0.41) SIRT3TDP1CYP2C9SLC22A12KDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023190826-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS 学校法人 高崎健康福祉大学 2023-10-05 WO disclosed
US-4352760-A Organic compounds substituted heptadeca-5,9- and 5,10-dienoic acid THE UPJOHN COMPANY (US) 1982-10-05 US disclosed
US-4349690-A ANTISECRETORY, ANTIULCER AGENTS, ANTICOAGULANTS AND ANTIAGGLOMERANTS THE UPJOHN COMPANY (US) 1982-09-14 US disclosed
US-4301078-A SMOOTH MUSCLE STIMULATORS THE UPJOHN COMPANY (US) 1981-11-17 US disclosed
US-4275213-A Isoxazolyl derivatives of 9α,11α-epoxy imino-9,11,15-trideoxy-PGF-type compounds THE UPJOHN COMPANY (US) 1981-06-23 US disclosed
US-4160095-A PROSTAGLANDINS; ANTIINFLAMMATORY AGENTS THE UPJOHN COMPANY (US) 1979-07-03 US disclosed
US-4157441-A PROSTAGLANDINS, ANTIINFLAMMATORY AGENTS THE UPJOHN COMPANY (US) 1979-06-05 US disclosed
US-4151351-A PROSTAGLANDINS, ANTIINFLAMMATORY THE UPJOHN COMPANY (US) 1979-04-24 US disclosed
US-4131738-A 6-Hydroxy-PGE1 compounds THE UPJOHN COMPANY (US) 1978-12-26 US disclosed
US-4128713-A 6,7-Didehydro-PGI1 compounds THE UPJOHN COMPANY (US) 1978-12-05 US disclosed
US-4126744-A PROSTACYCLIN, MUSCLE STIMULANTS, PLATELET AGGREGATION INHIBITORS THE UPJOHN COMPANY (US) 1978-11-21 US disclosed
US-4112224-A PROSTAGLANDIN THE UPJOHN COMPANY (US) 1978-09-05 US disclosed
US-4109082-A PROSTACYCLIN ANALOGS; SMOOTH MUSCLE STIMULATORS THE UPJOHN COMPANY (US) 1978-08-22 US disclosed
US-4100192-A Inter-phenylene-PG amides THE UPJOHN COMPANY (US) 1978-07-11 US disclosed
US-4097489-A PROSTAGLANDINS THE UPJOHN COMPANY (US) 1978-06-27 US disclosed