SCHEMBL11279679

SCHEMBL11279679

CC(C)CC(C)C(=O)Oc1ccc(C(=O)CNC(C)(C)C)cc1OC(=O)C(C)CC(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 1/20 0.38
ALOX15 P16050 2/20 0.36
ADRB2 P07550 4/20 0.36
ADRA2A P08913 1/20 0.36
DRD2 P14416 1/20 0.36
ADRA2C P18825 1/20 0.36
DRD1 P21728 1/20 0.36
ADRA1A P35348 1/20 0.36
DRD3 P35462 1/20 0.36
TAS1R3 Q7RTX0 4/20 0.36
TAS1R1 Q7RTX1 4/20 0.36
TSHR P16473 2/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 2/20 0.34
TP53 P04637 1/20 0.34
MAPT P10636 2/20 0.34
ADRB1 P08588 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11283584 0.88 ADRB2 (0.37) PDK1ALOX15ADRB2ADRA2ADRD2
SCHEMBL11279275 0.87 ALOX15 (0.49) PDK1ALOX15ADRB2ADRA2ADRD2
Hydrochloric Acid SCHEMBL11277586 0.86 ALOX15 (0.48) PDK1ALOX15ADRB2ADRA2ADRD2
Hydrochloric Acid SCHEMBL11276281 0.82 ALOX15 (0.49) ALOX15ADRB2TSHRALDH1A1KDM4E
SCHEMBL11285046 0.81 PTGS1 (0.39) ALOX15ADRB2ADRA2ADRD2ADRA2C
SCHEMBL11420372 0.81 PDE4D (0.35) PDK1ALOX15ADRB2ADRA2ADRD2
SCHEMBL11290594 0.79 ALDH1A1 (0.48) ADRB2TSHRALDH1A1KDM4EGAA
SCHEMBL11288059 0.79 ALOX15 (0.45) ALOX15ADRB2ALDH1A1LMNACYP3A4
Hydrochloric Acid SCHEMBL11278977 0.79 ALDH1A1 (0.37) ALOX15ADRB2TSHRALDH1A1KDM4E
Benzene SCHEMBL11287558 0.78 TSHR (0.56) TSHRALDH1A1KDM4EGAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US disclosed
US-RE30241-E BRONCHODILATION, ADRENERGIC STIMULANTS STERLING DRUG INC. (US) 1980-03-25 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed