Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.47 |
| ▸ | DRD1 | P21728 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14352419 | 0.79 | MEN1 (0.53) | CYP1A2KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL725002 | 0.78 | DRD2 (0.49) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11119265 | 0.74 | HRH4 (0.45) | DRD2HTR7HTR2AHTR6HTR1A | |
| SCHEMBL4431761 | 0.72 | DRD2 (0.57) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL167601 | 0.71 | DRD2 (0.74) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL141985 | 0.71 | HRH4 (0.71) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3410493 | 0.71 | CHRM1 (0.74) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29969899 | 0.71 | DRD2 (0.74) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8311 | 0.70 | DRD2 (1.00) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29368614 | 0.70 | DRD2 (1.00) | DRD2CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4355031-A | 2,3-Dihydro-3-[4-(substituted)-1-piperazinyl]-1H-isoindol-1-ones | AMERICAN HOME PRODUCTS CORP. (US) | 1982-10-19 | — | — | US | disclosed |