SCHEMBL725002

SCHEMBL725002

O=C1Cc2ccccc2C(N2CCNCC2)=N1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 5/20 0.49
HRH4 Q9H3N8 2/20 0.48
GABRP O00591 1/20 0.45
GABRD O14764 1/20 0.45
GABRA1 P14867 1/20 0.45
GABRB1 P18505 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
GABRA2 P47869 1/20 0.45
GABRB2 P47870 1/20 0.45
GABRA4 P48169 1/20 0.45
GABRE P78334 1/20 0.45
GABRA6 Q16445 1/20 0.45
GABRG1 Q8N1C3 1/20 0.45
GABRG3 Q99928 1/20 0.45
GABRQ Q9UN88 1/20 0.45
CYP1A2 P05177 2/20 0.43
CHRM2 P08172 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL141985 0.82 HRH4 (0.71) DRD2HRH4GABRPGABRDGABRA1
SCHEMBL11279898 0.78 DRD2 (0.54) DRD2HRH4CYP1A2CHRM2CHRM4
SCHEMBL11119265 0.76 HRH4 (0.45) DRD2HRH4GABRPGABRDGABRA1
SCHEMBL3408007 0.74 DRD2 (0.63) DRD2HRH4GABRA1GABRA2GABRB2
SCHEMBL3411698 0.74 MAPK1 (0.76) DRD2HRH4GABRPGABRDGABRA1
SCHEMBL16112076 0.72 NOS3 (0.46) DRD2HRH4GABRPGABRDGABRA1
Anthrone SCHEMBL28063735 0.69 MAOA (0.78) CYP1A2MAOAHTR2CKDM4EMEN1
SCHEMBL3410493 0.67 CHRM1 (0.74) DRD2HRH4GABRA1GABRA2GABRB2
SCHEMBL29969899 0.67 DRD2 (0.74) DRD2HRH4CYP1A2CHRM2CHRM4
SCHEMBL167601 0.67 DRD2 (0.74) DRD2HRH4CYP1A2CHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025155-A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES NOVARTIS AG (CH) 2012-03-01 WO disclosed