Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.98 |
| ▸ | GAA | P10253 | 2/20 | 0.98 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1540091 | 0.82 | ALDH1A1 (0.70) | ALDH1A1MAPK1GAANPC1RAB9A | |
| SCHEMBL3579979 | 0.80 | KMT2A (0.76) | ALDH1A1MAPK1GAANPC1RAB9A | |
| SCHEMBL11700991 | 0.79 | KMT2A (0.73) | ALDH1A1MAPK1GAANPC1RAB9A | |
| SCHEMBL12335742 | 0.77 | CYP1A2 (0.65) | ALDH1A1MAPK1GAAKMT2AHSD17B10 | |
| SCHEMBL42334 | 0.76 | RAB9A (0.97) | ALDH1A1MAPK1GAANPC1RAB9A | |
| SCHEMBL276275 | 0.73 | ALDH1A1 (0.62) | ALDH1A1MAPK1GAANPC1RAB9A | |
| SCHEMBL7721970 | 0.73 | HSD17B10 (0.69) | ALDH1A1MAPK1GAANPC1RAB9A | |
| SCHEMBL13186300 | 0.73 | ALDH1A1 (0.58) | ALDH1A1MAPK1GAARAB9AKMT2A | |
| SCHEMBL3586328 | 0.73 | RAB9A (0.77) | ALDH1A1MAPK1GAANPC1RAB9A | |
| SCHEMBL1540033 | 0.72 | LCK (0.74) | ALDH1A1MAPK1GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57183768-A | — | — | None | — | — | JP | disclosed |
| JP-S57183768-A | 4-METHYL-5-(O-CARBOXYPHENYL)CARBAMOYLTHIAZOLE DERIVATIVE AND ITS PREPARATION | KANTO ISHI PHARMA CO LTD | 1982-11-12 | — | — | JP | disclosed |