Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11185213 | 0.79 | ALDH1A1 (0.36) | SMN1; SMN2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL27720617 | 0.79 | MAPT (0.38) | SMN1; SMN2KDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7298529 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL11062501 | 0.77 | KDM4E (0.54) | SMN1; SMN2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL11163714 | 0.77 | SMN1; SMN2 (0.47) | TNFSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL11159308 | 0.77 | TDP1 (0.48) | TNFSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL11689706 | 0.74 | AKR1B1 (0.66) | TNFSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL10793457 | 0.69 | ALDH1A1 (0.55) | TNFSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL29729685 | 0.68 | KMT2A (0.62) | KDM4EALDH1A1HPGDL3MBTL1MAPT | |
| SCHEMBL845701 | 0.68 | KMT2A (0.62) | KDM4EALDH1A1HPGDL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4359423-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1982-11-16 | — | — | US | disclosed |
| EP-0024807-A1 | Benzocycloheptapyrrolealkanoic acids and their derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-03-11 | — | — | EP | disclosed |