Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939109 | 0.86 | PTPN1 (0.52) | NPC1RAB9AALDH1A1MCL1POLB | |
| SCHEMBL9868496 | 0.85 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9AMCL1POLB | |
| SCHEMBL1465160 | 0.83 | NOD2 (0.47) | SMN1; SMN2L3MBTL1RAB9AALDH1A1KDM4E | |
| SCHEMBL2343924 | 0.80 | MCL1 (0.57) | NPC1RAB9AALDH1A1MCL1POLB | |
| SCHEMBL29255654 | 0.80 | MCL1 (0.53) | NPC1RAB9AMCL1POLB | |
| SCHEMBL30042365 | 0.80 | MCL1 (0.57) | NPC1RAB9AALDH1A1MCL1POLB | |
| SCHEMBL2592562 | 0.78 | MCL1 (0.51) | NPC1RAB9AMCL1POLB | |
| SCHEMBL27720617 | 0.78 | MAPT (0.38) | SMN1; SMN2L3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL11280332 | 0.78 | TNF (0.46) | SMN1; SMN2L3MBTL1RAB9AALDH1A1POLB | |
| SCHEMBL1466287 | 0.78 | L3MBTL1 (0.55) | L3MBTL1NOD2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385722-B1 | Tricyclic lactam derivatives and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5013733-A | Psychological disorders, antianxiety, 5-hydroxytryptamine antagonists | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |
| EP-0385722-A2 | Tricyclic lactam derivatives and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |