SCHEMBL1128068

SCHEMBL1128068

CN/C(C)=C\C(=O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.60
RAB9A P51151 7/20 0.60
NPC1 O15118 5/20 0.60
GAA P10253 5/20 0.60
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
THRB P10828 1/20 0.60
MAPK1 P28482 4/20 0.55
SMN1; SMN2 Q16637 3/20 0.55
POLB P06746 1/20 0.55
TP53 P04637 1/20 0.55
HSD17B10 Q99714 1/20 0.55
NFE2L2 Q16236 1/20 0.55
ALDH1A1 P00352 5/20 0.54
HPGD P15428 3/20 0.54
KDM4E B2RXH2 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1128069 1.00 MAPT (0.60) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3060575 0.84 MAPT (0.60) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3060571 0.84 MAPT (0.60) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3078217 0.81 MAPT (0.81) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3078221 0.81 MAPT (0.81) MAPTRAB9ANPC1GAAMEN1
SCHEMBL14482116 0.81 MAPT (0.81) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3078356 0.79 ALDH1A1 (0.61) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3058494 0.79 MAPT (0.55) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3078353 0.79 ALDH1A1 (0.61) MAPTRAB9ANPC1GAAMEN1
SCHEMBL3058497 0.79 MAPT (0.55) MAPTRAB9ANPC1GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170327625-A1 COMPOSITIONS COMPRISING A POLYMERIC NETWORK ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (FR) 2017-11-16 US disclosed
US-9669243-B2 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2017-06-06 US disclosed
WO-2012024652-A3 SYSTEM AND METHODS FOR IMPROVED EFFICIENCY COMPRESSION IGNITION INTERNAL COMBUSTION ENGINE CONTROL TULA TECHNOLOGY, INC. (US) 2012-05-10 WO disclosed
EP-2282716-A2 DELIVERY OF HYDROPHOBIC BENEFIT AGENTS FROM BODYWASHES AND THE LIKE ONTO A KERATINOUS SUBSTRATE BASF SE (DE) 2011-02-16 EP disclosed
US-7833331-B2 Non-toxic corrosion-protection pigments based on cobalt UNIVERSITY OF DAYTON (US) 2010-11-16 US disclosed
US-7789958-B2 Non-toxic corrosion-protection pigments based on manganese UNIVERSITY OF DAYTON (US) 2010-09-07 US disclosed
US-20100135936-A1 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2010-06-03 US disclosed
EP-2152230-A2 SUNSCREEN COMPOSTIONS COMPRISING A RANDOM TERPOLYMER BASF SE (DE) 2010-02-17 EP disclosed
EP-2129363-A2 SUNSCREEN AND PERSONAL CARE COMPOSITIONS COMPRISING A SELECT COPOLYMER BASF SE (DE) 2009-12-09 EP disclosed
WO-2009130144-A2 DELIVERY OF HYDROPHOBIC BENEFIT AGENTS FROM BODYWASHES AND THE LIKE ONTO A KERATINOUS SUBSTRATE BASF SE (DE) 2009-10-29 WO disclosed
US-6521217-B1 Pulverizating cosmetic carriers and ultraviolet radiation absorbers comprising triazines, amides, benzotriazoles or benzimidazoles, in water in oil or an oil-in-water emulsions to form protective coatings or suntan lotions CIBA SPECIALTY CHEMICALS CORPORATION 2003-02-18 US disclosed
US-20020155073-A1 Use of mixtures of micropigments for preventing tanning and for lightening skin and hair FANKHAUSER PETER (CH) 2002-10-24 US disclosed
EP-1187598-A1 MICROPIGMENT MIXTURE Ciba SC Holding AG (CH) 2002-03-20 EP disclosed
US-6235271-B1 A SUNSCREEN AGENT COMPRISING A MICRONIZED ORGANIC ULTRAVIOLET ABSORBER, AN OIL SOLUBLE, NON-MICRONIZED ULTRAVIOLET ABSORBER AND/OR INORGANIC MICROPIGMENT AND A COPOLYMER OF ACRYLIC ACID-STYRENE AS HOLLOW SPHERE CIBA SPECIALTY CHEMICALS CORPORATION 2001-05-22 US disclosed
EP-1089706-A1 SUN SCREEN FORMULATIONS Ciba SC Holding AG (CH) 2001-04-11 EP disclosed
EP-1068866-A2 Use of mixtures of micropigments for prevening tannig and to induce skin and hair lightening Ciba SC Holding AG (CH) 2001-01-17 EP disclosed
WO-2000078277-A1 MICROPIGMENT MIXTURE CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-12-28 WO disclosed
WO-1999066896-A1 SUN SCREEN FORMULATIONS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1999-12-29 WO disclosed
EP-0893119-A1 UV-protection formulation Ciba SC Holding AG (CH) 1999-01-27 EP disclosed
US-4042646-A BETA-AMINO-ALPHA, BETA-UNSATURATED KETONE, POLYESTERS NIHON YUSHI CO., LTD. (JA) 1977-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170327625-A1 COMPOSITIONS COMPRISING A POLYMERIC NETWORK CHRNA5, CHRNA1, CHRM1 MAPT 2907/4885RAB9A 4471/4885NPC1 3275/4885
US-20020155073-A1 Use of mixtures of micropigments for preventing tanning and for lightening skin and hair MITF, TYR, CUTA MAPT 225/4885RAB9A 3777/4885NPC1 2564/4885
US-20100135936-A1 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate KRT18, ABHD16A, CUTA MAPT 3019/4885RAB9A 4122/4885NPC1 2885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.