SCHEMBL11283253

SCHEMBL11283253

O=C(c1nc(Cl)c(Cl)[nH]1)C(Cl)Cl

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
PTPRB P23467 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2824127 0.76 KDM4E (0.53) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
Water SCHEMBL11160916 0.74 KDM4E (0.52) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
SCHEMBL11184996 0.74 SCN9A (0.38) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
SCHEMBL11283559 0.74 KDM4E (0.34) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
SCHEMBL11276440 0.71 KDM4E (0.32) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
SCHEMBL11280815 0.71 GSK3B (0.33) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
SCHEMBL11286616 0.71 GSK3B (0.36) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
SCHEMBL11168745 0.69 ALOX15 (0.44) KDM4ECYP3A4CYP2C9PTPRBHSD17B10
SCHEMBL11166561 0.69 RIPK1 (0.33) KDM4E
SCHEMBL11163748 0.69 NPSR1 (0.41) KDM4ECYP3A4CYP2C9PTPRBHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0013905-B1 4,5-DICHLORO-IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS HERBICIDES BAYER AG (DE) 1982-05-05 EP disclosed
EP-0013905-A1 4,5-Dichloro-imidazole derivatives, their preparation and their application as herbicides BAYER AG (DE) 1980-08-06 EP disclosed