Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483081 | 0.82 | TDP1 (0.61) | ALDH1A1LMNASMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL11065543 | 0.81 | LMNA (0.67) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL8101551 | 0.81 | MEN1 (0.52) | ALDH1A1PLOD2EPHX2CYP2C9CYP2C19 | |
| SCHEMBL9292468 | 0.80 | ALDH1A1 (0.59) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL11820789 | 0.80 | ALDH1A1 (0.55) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL7147666 | 0.80 | ALDH1A1 (0.55) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL9603054 | 0.80 | ALDH1A1 (0.55) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL6203223 | 0.80 | ALDH1A1 (0.55) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL27566013 | 0.79 | ALDH1A1 (0.58) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL30641184 | 0.79 | ALDH1A1 (0.57) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008755-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-NITROIMIDAZOLES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-21 | — | — | EP | disclosed |
| US-4251535-A | ANTIARTHRITIC AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4199592-A | Antiinflammatory 4,5-diaryl-2-nitroimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| EP-0008755-A1 | Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-03-19 | — | — | EP | disclosed |