Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11272830 | 0.95 | KMT2A (0.58) | KMT2AMEN1POLBATMTDP1 | |
| SCHEMBL11278725 | 0.95 | KMT2A (0.58) | KMT2AMEN1POLBATMTDP1 | |
| SCHEMBL11270445 | 0.95 | KMT2A (0.58) | KMT2AMEN1POLBATMTDP1 | |
| SCHEMBL11282367 | 0.94 | KMT2A (0.59) | KMT2AMEN1POLBATMTDP1 | |
| SCHEMBL11282296 | 0.92 | KMT2A (0.56) | KMT2AMEN1POLBATMTDP1 | |
| SCHEMBL11285504 | 0.90 | KMT2A (0.52) | KMT2AMEN1POLBATMALDH1A1 | |
| SCHEMBL11285568 | 0.86 | KMT2A (0.54) | KMT2AMEN1POLBATMALDH1A1 | |
| SCHEMBL11277590 | 0.86 | KMT2A (0.54) | KMT2AMEN1POLBATMALDH1A1 | |
| SCHEMBL11272631 | 0.86 | SMN1; SMN2 (0.56) | KMT2AMEN1POLBATMALDH1A1 | |
| SCHEMBL11281075 | 0.86 | SMN1; SMN2 (0.56) | KMT2AMEN1POLBATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4310533-A | INHIBITING PLASMIN AND-OR TRYSIN ACTIVITY | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-01-12 | — | — | US | disclosed |