Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.59 |
| ▸ | AR | P10275 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 5/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288394 | 0.96 | PGR (0.58) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL11424745 | 0.95 | PGR (0.57) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL7598319 | 0.94 | PGR (0.61) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL11433111 | 0.93 | PGR (0.58) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL11438462 | 0.92 | ABCB11 (0.63) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL8918368 | 0.92 | PGR (0.67) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL11423796 | 0.91 | PGR (0.66) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL11438787 | 0.91 | PGR (0.62) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL11429769 | 0.91 | PGR (0.62) | PGRARCYP3A4NR3C1ABCB11 | |
| SCHEMBL11289212 | 0.91 | PGR (0.56) | PGRARCYP3A4NR3C1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000742-B1 | CORTICOIDS-17-ALKYLCARBONATES, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-12 | — | — | EP | disclosed |
| US-4242334-A | ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-12-30 | — | — | US | disclosed |
| EP-0000742-A1 | Corticoids-17-alkylcarbonates, process for their preparation and preparations containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-02-21 | — | — | EP | disclosed |