Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11309137 | 0.92 | HTT (0.44) | HTTTSHRALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL11320629 | 0.91 | HTT (0.43) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11053001 | 0.89 | ALDH1A1 (0.50) | ALDH1A1KMT2ALMNAPOLBHPGD | |
| SCHEMBL11279723 | 0.88 | HTT (0.42) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11059296 | 0.88 | RAPGEF4 (0.42) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL10732669 | 0.87 | HTT (0.40) | HTTTSHRALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL11414461 | 0.87 | RAPGEF4 (0.41) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11436815 | 0.85 | HTT (0.40) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11278607 | 0.85 | HTT (0.39) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11420739 | 0.85 | ALDH1A1 (0.44) | HTTTSHRALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216229-A | 1-AMIDINO-3-PHENYLUREAS | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | claimed |
| US-4216230-A | Method for alleviating hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | claimed |
| US-4150154-A | GASTROINTESTINAL ANTISPASMODICS | WILLIAM H. RORER, INC. (US) | 1979-04-17 | — | — | US | claimed |
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4216229-A | 1-AMIDINO-3-PHENYLUREAS | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216230-A | Method for alleviating hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4183956-A | Method for treating gastrointestinal spasms, gastrointestinal hyperacidity and hypertensive disorders with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-01-15 | — | — | US | disclosed |
| US-4150154-A | GASTROINTESTINAL ANTISPASMODICS | WILLIAM H. RORER, INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |